The sickle cell disease are a group of hemoglobin disorders characterized by red cells that undergo sickle shape transformation when they are deoxygenated. Sickle cell disease is transmitted as an autosomal recessive trait. This unusual property,
due to
the polymerization of sickle hemoglobin results in anemia and vasoocclusive complication, The most clinical significant of these disease are sickle cell anemia, sickle cell hemoglobin C disease, and sickle cell beta thalassemia. Symptoms of
pallor,
fever, abdominal and joint pain, enlargement of the liver and spllen, swelling of hands and feet first appear near the latter part of the first year of life. Intravascular sickling affects all organs. For clinical and therapeutic purposes,
exacerbations
may be classified as vasoocclusive or pain, aplastic, hemolytic or sequestration crisis. We experienced a 22 year old female patient who suffered severe multiple joint pain and back. Pain though to be caused by vase-occlussive phenomena.
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